Unit 5 Genomics and Technology Assignments
The Human Genome Project
links to videos from class:
- Sequencing the First Human Genome http://unlockinglifescode.org/node/649
- Making Sense of the Human Genome http://unlockinglifescode.org/node/650
- Hank and Sci Show HGP Surprises http://www.youtube.com/watch?v=F5LzKupeHtw
- TED talk, Genomic Revolution http://www.youtube.com/watch?v=u8bsCiq6hvM
- Visions of the Future http://unlockinglifescode.org/node/651
fyi- Genomics career exploration -http://www.genome.gov/GenomicCareers/index.cfm
links to videos from class:
- Sequencing the First Human Genome http://unlockinglifescode.org/node/649
- Making Sense of the Human Genome http://unlockinglifescode.org/node/650
- Hank and Sci Show HGP Surprises http://www.youtube.com/watch?v=F5LzKupeHtw
- TED talk, Genomic Revolution http://www.youtube.com/watch?v=u8bsCiq6hvM
- Visions of the Future http://unlockinglifescode.org/node/651
fyi- Genomics career exploration -http://www.genome.gov/GenomicCareers/index.cfm
Genome Sequencing Projects (posters or concept maps)
Check out just how much sequencing information is known!
NCBI Genome http://www.ncbi.nlm.nih.gov/genome/
- Department of Energy, Joint Genome Institute, explore within Science Programs
- 1000 Genomes Project
- Genome 10k Project
- Human Microbiome Project
-100,000 Genomes Project
-Autism 10k project
-African Genome Variation Project, Sanger Center project scope
-J Craig Venter Institute
Check out just how much sequencing information is known!
NCBI Genome http://www.ncbi.nlm.nih.gov/genome/
- Department of Energy, Joint Genome Institute, explore within Science Programs
- 1000 Genomes Project
- Genome 10k Project
- Human Microbiome Project
-100,000 Genomes Project
-Autism 10k project
-African Genome Variation Project, Sanger Center project scope
-J Craig Venter Institute
Microarrays
1) Review Microarrays on LearnGenetics. Select Chapters 1 and 2 if additional background information on microarrays is needed; Chapter 3 is the interactive experiment. Click the microarray to begin. Write a summary statement from completing the interactive. What did you learn? http://learn.genetics.utah.edu/content/labs/microarray/ 2) Answer the questions on the homework handout.
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Pharmacogenomics
Examine the FDA list of drugs with genetic indications for one related to your multifactorial disease project. NOTE the gene name (biomarker, 3rd column) and WHICH SECTION OF THE LABEL WILL CONTAIN THE GENETIC INFORMATION (last column of the table). http://www.fda.gov/drugs/scienceresearch/researchareas/pharmacogenetics/ucm083378.htm Right click on the name of the drug to open the drug page of interest in another window. Click on the hyperlink of the drug in the new window to open the detailed information page. Midway down the page, click on the "Label Information" link (orange bullet point). Click on/open the most recent label revision file. Within the label document, read the sections of the label that contain genetic information (last column from the initial FDA page) and paraphrase the information about the genetic effect (biomarker) Go to the Genetics Home Reference page for the gene (biomarker), and describe the normal protein function. http://ghr.nlm.nih.gov/BrowseGenes Submit your homework assignment by completing the Submission form (launched from button below). HW clarification. There are only a limited number of drugs that have biomarkers. The purpose of the assignment is to get an appreciation for the field of pharmacogenomics and the current breadth of information. Although finding a drug in the same therapeutic area as your weebly assignment is ideal, not all multifactorial disorders will have known biomarkers. If your therapeutic area does not have a drug with a biomarker, you may select any drug/therapeutic area and its associated biomarker (protein) for the homework assignment.
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Clinical Trials
Write a scenario, pretending you are a patient with the disorder you researched for your weebly project. Identify and describe an ongoing clinical trial, including the phase, purpose, and selection criteria. https://clinicaltrials.gov/ct2/home
Would you (as the imaginary patient) participate? Describe why or why not, citing at least two different reasons.
Write a scenario, pretending you are a patient with the disorder you researched for your weebly project. Identify and describe an ongoing clinical trial, including the phase, purpose, and selection criteria. https://clinicaltrials.gov/ct2/home
Would you (as the imaginary patient) participate? Describe why or why not, citing at least two different reasons.
*If you are unable to find a clinical trial for your disorder, select a related disorder or something you are interested in to complete the homework. The purpose of the assignment is to explore recent/ongoing clinical trials and practice the key vocabulary from the clinical trials lesson. Submit your homework using this form: https://docs.google.com/a/wcpss.net/forms/d/14XeNaTyEl0CVmORa_GS4maJlnHhWxB9GfOQ6mlIvjbc/viewform
Epigenetics - Blackboard Discussion submission
Locate and summarize an article which links the field of epigenetics/epigenomics to the condition you research for your weebly site. Use a science summary site (Science Daily, Science News, Science Magazine), or a primary article site (such as Science Direct through the Wake Tech Library or NCBI Pubmed). If your initial searches are not successful for your weebly condition and epigenetics or epigenomics, choose another condition you are interested in learning more about the role of epigenetics.
For full credit on your post, please include:
- the article title
- the hyperlink to the article
- the key findings from the article
- what you wonder following reading the article
- an insightful comment on another post
Locate and summarize an article which links the field of epigenetics/epigenomics to the condition you research for your weebly site. Use a science summary site (Science Daily, Science News, Science Magazine), or a primary article site (such as Science Direct through the Wake Tech Library or NCBI Pubmed). If your initial searches are not successful for your weebly condition and epigenetics or epigenomics, choose another condition you are interested in learning more about the role of epigenetics.
For full credit on your post, please include:
- the article title
- the hyperlink to the article
- the key findings from the article
- what you wonder following reading the article
- an insightful comment on another post